capstone discussion outline sickle cell disease H e a l t h M e d i c a l

Capstone
Discussion Outline

Sickle cell disease is a
hereditary blood disorder that is moved down through families. Both parents
need to carry the sickle cell gene for their child to have it. In sickle cell
disease, glutamic acid in beta chain of hemoglobin is supplanted by valine at
position 6. It can bring about sickling of red blood cells, which lessens their
flexibility and oxygen carrying capacity. Typical red blood cells are round or
biconcave disc shaped and highly elastic. There is no generally accessible cure
for Sickle Cell Disease. However, a little number of kids with Sickle Cell
Disease have been cured through stem cell transplant.

Stem cells are cells that can
form into a wide range of cells in the body. They serve as a repair framework
for the body. Stem cells are found in bone marrow. This is the elastic tissue
inside a few bones, similar to your hip and thigh bones. Stem cells
additionally are found in umbilical cord blood, the blood in the umbilical cord
and placenta. This blood can be collected after the umbilical cord is cut
during childbirth.

In a stem cell transplant for
SCD, stem cells taken from a healthy individual are put into a man with SCD.
This system is extremely hazardous and can have genuine reactions, including
death.

The stem cell gene therapy
system portrayed in the study seeks to amend the change in the beta-globin
chain so bone marrow stem cells produce ordinary, circular shaped blood cells.
The method utilized extraordinarily engineered enzymes, called zinc-finger
nucleases, to wipe out the changed hereditary code and replace it with a
corrected version that repairs the beta-globin mutation. 

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